The Use of Biochemical Cardiac Markers in Acute Coronary Syndrome

Authors

  • Akhtar Munir Department of Microbiology, Gomal University Dera Ismail Khan, KPK, Pakistan.

Keywords:

Acute Coronary Syndrome, Biomarkers, High sensitivity cardiac troponin, B-type Natriuretic peptide

Abstract

Every year, acute coronary syndrome (ACS), one of the main causes of death worldwide, is getting more prevalent. Reduced myocardial blood flow is the hallmark of the recently identified medical illness known as acute coronary syndrome. Biochemical cardiac indicators in blood serum are essential for people's early syndrome detection and risk assessment, in addition to an ECG, ECG, and coronary angiography. Numerous biochemical cardiac indicators, such as myoglobin, creatine kinase-MB, aspartate aminotransferase (AST) activity, lactate dehydrogenase (LDH), and cardiac troponin (cTnT and cTnI), are used to detect acute coronary syndrome. However, it is believed that amino-terminal proBNP, B-type natriuretic peptide (BNP), and high-sensitivity cardiac troponin (hs-cTn) are the best markers for identifying those with acute coronary syndrome. They have the highest specificities and sensitivity, which explains why. This review paper covers almost all biochemical cardiac markers and discusses current research on acute coronary syndrome.

References

. Marieb, E. N., & Hoehn, K. (2018). Human Anatomy & Physiology (10th ed.). Pearson

. Guyton, A. C., & Hall, J. E. (2015). Textbook of Medical Physiology (13th ed.). Elsevier.

. Berne, R. M., & Levy, M. N. (2017). Cardiovascular Physiology (11th ed.). Elsevier.

. Wu, A. H. (2003). Cardiac markers. Springer Science & Business Media.

. Li, L., Zhou, Q., & Xu, J. (2020). Changes of laboratory cardiac markers and mechanisms of cardiac injury in coronavirus diseases.

. Makki, N., Brennan, T. M., & Girotra, S. (2015). Acute coronary syndrome. Journal of intensive care medicine, 30(4), 186-200.

. Overbaugh, K. J. (2009). Acute coronary syndrome. AJN The American Journal of Nursing, 109(5), 42-52.

. Lewandrowski, K., Chen, A., & Januzzi, J. (2002). Cardiac markers for myocardial infarction: a brief review. Pathology Patterns Reviews, 118(suppl_1), S93-S99.

. Collinson, P. O., & Chamberlain, L. (2001). Cardiac markers in the diagnosis of acute coronary syndromes. Current cardiology reports, 3(4), 280-288.

. Puleo, P. R., Guadagno, P. A., Roberts, R., Scheel, M. V., Marian, A. J., Churchill, D., & Perryman, M. B. (1990). Early diagnosis of acute myocardial infarction based on assay for subforms of creatine kinase-MB. Circulation, 82(3), 759-764.

. Panteghini, M., Pagani, F., & Cuccia, C. (1987). Activity of serum aspartate aminotransferase isoenzymes in patients with acute myocardial infarction. Clinical chemistry, 33(1), 67-71.

. Herzog, E., & Chaudhry, F. (2009). Echocardiography in Acute Coronary Syndrome. https://doi.org/10.1007/978-1-84882-027-2

. Gibler, W. B., Gibler, C. D., Weinshenker, E., Abbottsmith, C., Hedges, J. R., Barsan, W. G., Sperling, M., Chen, I.-W., Embry, S., & Kereiakes, D. (1987). Myoglobin as an early indicator of acute myocardial infarction. Annals of emergency medicine, 16(8), 851-856.

. Reichlin, T., Hochholzer, W., Bassetti, S., Steuer, S., Stelzig, C., Hartwiger, S., Biedert, S., Schaub, N., Buerge, C., & Potocki, M. (2009). Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. New England Journal of Medicine, 361(9), 858-867.

. Adams, J. E., Sicard, G. A., Allen, B. T., Bridwell, K. H., Lenke, L. G., Davila-Roman, V. G., Bodor, G. S., Ladenson, J. H., & Jaffe, A. S. (1994). Diagnosis of perioperative myocardial infarction with measurement of cardiac troponin I. New England Journal of Medicine, 330(10), 670-674.

. Wu, Y., Pan, N., An, Y., Xu, M., Tan, L., & Zhang, L. (2020). Diagnostic and Prognostic Biomarkers for Myocardial Infarction. Front Cardiovasc Med, 7, 617277.

. Mueller, C. (2014). Biomarkers and acute coronary syndromes: an update. Eur Heart J, 35(9), 552-556.

. Dekker, M. S., Mosterd, A., van 't Hof, A. W., & Hoes, A. W. (2010). Novel biochemical markers in suspected acute coronary syndrome: systematic review and critical appraisal. Heart,96(13), 1001-1010.

. Morrow, D. A., & Braunwald, E. (2003). Future of biomarkers in acute coronary syndromes: moving toward a multimarker strategy. Circulation, 108(3), 250-252.

. Tilea, I., Varga, A., & Serban, R. C. (2021). Past, Present, and Future of Blood Biomarkers for the Diagnosis of Acute Myocardial Infarction-Promises and Challenges. Diagnostics (Basel), 11(5)

. Herzog, E., & Chaudhry, F. (2009). Echocardiography in Acute Coronary Syndrome. https://doi.org/10.1007/978-1-84882-027-2

. Mendonça da Silva Correia, B. V. (2021). Clinical Cardiac Markers for Acute Myocardial Infarction Diagnostic. American Journal of Biomedical Science & Research, 13(5), 580-591.

. Garg, P., Morris, P., Fazlanie, A. L., Vijayan, S., Dancso, B., Dastidar, A. G., Plein, S., Mueller, C., & Haaf, P. (2017). Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin. Intern Emerg Med, 12(2), 147-155. https://doi.org/10.1007/s11739-017-1612-1

. del Val Martin, D., Sanmartín Fernández, M., & Zamorano Gómez, J. L. (2015). Biomarkers in acute coronary syndrome. IJC Metabolic & Endocrine, 8, 20-23.

. Christenson, E., & Christenson, R. H. (2013). The role of cardiac biomarkers in the diagnosis and management of patients presenting with suspected acute coronary syndrome. Ann Lab Med, 33(5), 309-318.

. Chacko, S. H., S. David Wallbridge, D & Harper, A. (2017). .

. Amodio, G., Antonelli, G., & Di Serio, F. (2010). Cardiac biomarkers in acute coronary syndromes: a review. Current vascular pharmacology, 8(3), 388-393.

. Al-Hadi, H. A., & Fox, K. A. (2009). Cardiac markers in the early diagnosis and management of patients with acute coronary syndrome. Sultan Qaboos University Medical Journal, 9(3), 231.

. Searle, J., Danne, O., Müller, C., & Mockel, M. (2011). Biomarkers in acute coronary syndrome and percutaneous coronary intervention. Minerva cardioangiologica, 59(3), 203-223.

. Tousoulis, D., Kampoli, A.-M., Stefanadi, E., Antoniades, C., Siasos, G., Papavassiliou, A. G., & Stefanadis, C. (2008). New biochemical markers in acute coronary syndromes. Current medicinal chemistry, 15(13), 1288-1296.

. Moe, K. T., & Wong, P. (2010). Current trends in diagnostic biomarkers of acute coronary syndrome. Ann Acad Med Singapore, 39(3), 210-215.

. Panteghini, M., Apple, F. S., Christenson, R. H., Dati, F., Mair, J., & Wu, A. H. (1999). Use of biochemical markers in acute coronary syndromes. IFCC Scientific Division, Committee on Standardization of Markers of Cardiac Damage.

. Apple, F. S., Wu, A. H., Mair, J., Ravkilde, J., Panteghini, M., Tate, J., Pagani, F., Christenson, R. H., Mockel, M., & Danne, O. (2005). Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clinical chemistry, 51(5), 810-824.

. Romić, E., Unić, A., Derek, L., & Pehar, M. (2009). Biochemical markers in the diagnosis of acute coronary syndrome. Acta Medica Croatica: Casopis Hravatske Akademije Medicinskih Znanosti, 63(1), 15-19.

. Raguz, M., Spoljarić, R., Vrazić, H., Raos, V., Sebetić, D., & Bergovec, M. (2009). The role of diagnostic work-up at university hospital emergency service and coronary care unit in the management of acute coronary syndrome patients. Acta Medica Croatica: Casopis Hravatske Akademije Medicinskih Znanosti, 63(1), 47-52.

. Azzazy, H. M., & Christenson, R. H. (2002). Cardiac markers of acute coronary syndromes: is there a case for point-of-care testing? Clinical biochemistry, 35(1), 13-27.

Downloads

Published

2024-01-16

Issue

Section

Review Paper
Loading...