Docetaxel: Strategy to Enhance Their Efficiency Using Polymeric Nanocomposite

Ayesha Bibi; Ajmal Shah; Maryam Israr; Shagufta Rani; Nayab  Tariq; Rabia Habib; Muhammad Ahsan; Mansoor Ali Khan

Docetaxel: Strategy to Enhance Their Efficiency Using Polymeric Nanocomposite

Authors

Ayesha Bibi Department of Chemistry Abdul Wali Khan University, Mardan 23200, KPK, Pakistan.
Ajmal Shah
Maryam Israr
Shagufta Rani
Nayab Tariq
Rabia Habib
Muhammad Ahsan
Mansoor Ali Khan

Keywords:

MNPs, @p(AN-co-AA-co-EGDMA), Docetaxel, Loading

Abstract

Docetaxel (DTX) is a semi-synthetic anticancer drug from the taxoid family. DTX is a good anti-mitotic anticancer agent that can be used to treat many types of human cancer. DTX does have some problems, such as not dissolving well in water, being highly poisonous overall, and not being distributed in a specific way. To solve these issues, researchers have been working on making nanocarriers that can carry DTX to the targeted site. Polymeric nanocomposites have gained great attention as carriers for drugs delivery. In this study, magnetite coated silica (MNPs@SiO₂) were made and covered with a polymer of organic ligands that is acrylonitrile (AN), acrylic acid (AA), and ethylene glycol dimethacrylate (EGDMA) to load the DTX. The polymeric nanocomposite (MNPs@SiO₂@p (AN-co-AA-co-EGDMA)) was collected as a white powder and studied using FTIR, EDX, and SEM techniques. The prepared polymeric nanocomposite was studied for loading of docetaxel. The effect of contact time, pH, and polymeric nanocomposite amount on the loading of the drug were also evaluated. The maximum loading for docetaxel (93.4%) was observed at 10mg of the polymeric nanocomposite, pH of 4, and time of 6 h.

References

. Korake S, Bothiraja C. and Pawar A. (2023). Design, development, and in-vitro/in-vivo evaluation of Docetaxel-loaded PEGylated Solid Lipid Nanoparticles in Prostate Cancer Therapy. Eur J Pharm Biopharm.

. Crabb SJ, Birtle AJ, Martin K, Downs N, Ratcliffe I, Maishman T, Ellis M, Griffiths G, Thompson S, Ksiazek L, and Khoo V. (2017). ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer. Invest New Drugs. 35: 599-607.

. Ganju A, Yallapu MM, Khan S, Behrman SW, Chauhan SC, and Jaggi M. (2014). Nanoways to overcome docetaxel resistance in prostate cancer. Drug Resist. Updat. 17(1-2): 13-23.

. Cho HJ, Park JW, Yoon IS, and Kim DD. (2014). Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake. Int J Nanomedicine. 495-504.

. Xu Z, Chen L, Gu W, Gao Y, Lin L, Zhang Z, Xi Y, and Li Y. (2009). The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma. Biomater. 30(2): 226-232.

. Vacca A, Ribatti D, Iurlaro M, Merchionne F, Nico B, Ria R, and Dammacco F. (2002). Docetaxel versus paclitaxel for antiangiogenesis. Stem Cell Res. 11(1): 103-118.

. Sumera Anwar A, Ovais M, Khan A, and Raza A. (2017). Docetaxel‐loaded solid lipid nanoparticles: a novel drug delivery system. IET J. Nanobiotechnology. 11(6): 621-629.

. Grant DS, Williams TL, Zahaczewsky M, and Dicker AP. (2003). Comparison of antiangiogenic activities using paclitaxel (taxol) and docetaxel (taxotere). Int. J. Cancer. 104(1): 121-129.

. Kobayashi D, Kawai N, Sato S, Naiki T, Yamada K, Yasui T, Tozawa K, Kobayashi T, Takahashi S, and Kohri K. (2013). Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model. Prostate 73(9): 913-922.

. Wang L, Zhang M, Zhang N, Shi J, Zhang H, Li M, Lu C, and Zhang Z. (2011). Synergistic enhancement of cancer therapy using a combination of docetaxel and photothermal ablation induced by single-walled carbon nanotubes. Int J Nanomedicine. 2641-2652.

. Dou J, Zhang H, Liu X, Zhang M, and Zhai G. (2014). Preparation and evaluation in vitro and in vivo of docetaxel loaded mixed micelles for oral administration. Colloids Surf. B. 114: 20-27.

. Khatun Z, Nurunnabi M, Reeck GR, Cho KJ, and Lee YK. (2013). Oral delivery of taurocholic acid linked heparin–docetaxel conjugates for cancer therapy. J.control.release. 170(1): 74-82.

. Thambiraj S, Vijayalakshmi R, and Ravi Shankaran D. (2021). An effective strategy for development of docetaxel encapsulated gold nanoformulations for treatment of prostate cancer. Sci. Rep 11(1): 2808.

. Albano JM, de Morais Ribeiro LN, Couto VM, Messias MB, da Silva GHR, Breitkreitz MC, de Paula E, and Pickholz M. (2019). Rational design of polymer-lipid nanoparticles for docetaxel delivery. Colloids Surf. B. 175: 56-64.

. Desale JP, Swami R, Kushwah V, Katiyar SS, and Jain S. (2018). Chemosensitizer and docetaxel-loaded albumin nanoparticle: overcoming drug resistance and improving therapeutic efficacy. Nanomed. J. 13(21): 2759-2776.

. Tarasi R, Khoobi M, Niknejad H, Ramazani A, Ma’mani L, Bahadorikhalili S, and Shafiee A. (2016). β-cyclodextrin functionalized poly (5-amidoisophthalicacid) grafted Fe3O4 magnetic nanoparticles: A novel biocompatible nanocomposite for targeted docetaxel delivery. J. Magn. Magn. Mater. 417: 451-459.

. Sharafi Z, Bakhshi B, Javidi J, and Adrangi S. (2018). Synthesis of silica-coated iron oxide nanoparticles: preventing aggregation without using additives or seed pretreatment. IJPR. 17(1): 386.

. Murugan E, Ariraman M, Rajendran S, Kathirvel J, Akshata CR, and Kumar K. (2018). Core–Shell Nanostructured Fe3O4–Poly (styrene-co-vinylbenzyl chloride) Grafted PPI Dendrimers Stabilized with AuNPs/PdNPs for Efficient Nuclease Activity. ACS omega. 3(10): 3685-13693.

. Shah N, Nisar N, Rehan T, Naeem M, and Ul-islam M. (2022). Microwave-assisted synthesis of a magnetic core–shell material composed of Fe3O4@ SiO2@ poly (methacrylamide-co-acrylic acid) for an anticancer drug loading. Appl. Nanosci. 12(11): 3547-3554.

. Sierra J, Palacios J, and VivaldoLima E. (2006). Effect of microwave activation on polymerization rate and molecular weight development in emulsion polymerization of methyl methacrylate. Journal of Macromolecular Science Part A: Pure Appl. Chem. 43(3): 589-600.

. Kempe K, Becer CR, and Schubert US. (2011). Microwave-assisted polymerizations: recent status and future perspectives. J. Biol. Macromol. 44(15): 5825-5842.

. Wiesbrock F, Hoogenboom R, and Schubert US. (2004). Microwave‐assisted polymer synthesis: state‐of‐the‐art and future perspectives. Macromol. Rapid Commun. 25(20): 1739-1764.

. Shi S. (2003). Microwave-assisted wet chemical synthesis: advantages, significance, and steps to industrialization. JMMCE. 2(02): 101.

. Wicki A, Witzigmann D, Balasubramanian V, and Huwyler J. (2015). Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. J Control Release. 200: 138-157.

. Xu X, Ho W, Zhang X, Bertrand, and Farokhzad O. (2015). Cancer nanomedicine: from targeted delivery to combination therapy. Trends. Mol. Med. . 21(4): 223-232.

. Yee Kuen C, and Masarudin MJ. (2022). Chitosan nanoparticle-based system: A new insight into the promising controlled release system for lung cancer treatment. Mol. 27(2): 473.

. Ummadi S, Shravani B, Rao NR, Reddy MS, and Sanjeev B. (2013). Overview on controlled release dosage form. Syst. J. 7(8): 51-60.

. Ahsan M, Qasim S, Shah A, Nawaz I, Kashif M, and Ahmad W, (2024). Loading of anticancer drug anastrozole using Fe3O4@SiO2. Braz. J. 3(2): 93-101.

. Javidi J, Esmaeilpour M, and Khansari MR. (2015). Synthesis, characterization and application of core–shell magnetic molecularly imprinted polymers for selective recognition of clozapine from human serum. RSC Adv. 5(89): 73268-73278.